Gender Impact on MACE Events in Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention: A Meta-analysis

Background
A differential impact of sex has been observed in patients undergoing percutaneous coronary intervention. Outcomes of females after Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI) have not been well studied

Methods
PubMed, EMBASE and Google Scholar databases were queried for all trials about CTO PCI. Trials reporting sex-based outcomes were included

Results
This meta-analysis of 6 CTO trials included 7353 patients, of whom 1319 (18%) were females. Female patients, compared to males, had higher odds of periprocedural bleeding (OR 0.36, 95% CI 0.22- 0.60), number needed to harm was 49.5. Females patients had similar odds of mortality, MACE, periprocedural MI, coronary perforation, and stroke compared to males

Conclusions
In this meta-analysis, female patients, compared to males, had increased odds of periprocedural bleeding and similar odds for overall peri-procedural MACE events after CTO PCI