The effect of pulmonary embolism (PE) or deep vein thrombosis (DVT) post Covid-19 diagnosis using a federated database.
Presenter
Sahil Dave, Charleston Area Medical Center, Charleston , WV
Frank Annie, PhD, CAMC Health Education and Research Institute, Charleston, SC, Sarah B Embrey, PharmD, University of Charleston, Charleston, WV, Sahil Dave, Charleston Area Medical Center, Charleston , WV and Aravinda Nanjundappa, M.B.B.S., FSCAI, Cleveland Clinic Main Campus, Cleveland, OH
Keywords: COVID-19, Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE)
Background
We sought to understand the effect of a pulmonary embolism (PE) or deep vein thrombosis (DVT) post Covid-19 diagnosis using a federated database.
Methods
We identified adult patients aged 18-90 that developed a PE/DVT from January 20
th 2020 to December 9
th 2020. Patients were divided into those that had a developed a PE and or DVT diagnosis post Covid-19 diagnosis and those that did not. We compared all-cause mortality between propensity matched (PSM) pairs of patients in the 2 groups.
Results
A total of 161,656 patients were included. Of those, 3,258 (2.0%) developed a PE-DVT post Covid-19 diagnosis and 158,398 (98.0%) did not. Patients in the PE/DVT group were older (60.8 ± 15.8 vs 44.9 ±17.4, P<0.001) and more likely to be male (53.4% vs 42.8%, P<0.001). They also had a high prevalence of key co-morbidities which include (hypertension, diabetes, CHF, COPD, CAD, and history of smoking). Patients that developed a PE/DVT had a 12.9%, (P<0.001) greater chance of all-cause mortality post Covid-19 diagnosis. This was also confirmed with a log-rank test with a survival probability of 73.1% vs 95.2% (P<0.001).
Conclusions
In a large multi-national database patients it appears that those that developed a PE/DVT had a major greater risk of all-cause mortality.
