The Effect SARS-COV-2 on Cases of TAVR
Presenter
Sahil Dave, Charleston Area Medical Center, Charleston , WV
Frank Annie, PhD, CAMC Health Education and Research Institute, Charleston, SC, Sahil Dave, Charleston Area Medical Center, Charleston , WV, Sarah B Embrey, PharmD, University of Charleston, Charleston, WV and Aravinda Nanjundappa, M.B.B.S., FSCAI, Cleveland Clinic Main Campus, Cleveland, OH
Keywords: TAVI/TAVR/Aortic Valve
Background
The effect of SARS-COV-2 on cases of aortic stenosis (AS) that will require a TAVR (Transcatheter Aortic Valve Replacement) is poorly understood, and the long term effects are not well reported. This research aims to determine if there is a difference in all-cause mortality as associated with the post SARS-COV-2 diagnosis versus those that did not have a positive lab diagnosis of SARS-COV-2.
Methods
We queried the TriNetx database (Covid-19 Research Network), a network of 56 health care organizations. We analyzed the data using the ICD 10 codes used for TAVR procedures from January 20
th 2020 to December 9
th 2020 and total of (n=2,117) patients between the two groups were identified. We identified (n=118) SARS-COV-2 TAVR and (n=1,997) non-SARS-COV-2 (TAVR). Descriptive statistics were used to measure association and Kaplan-Meier Survival Curve were utilized to assess the endpoints of mortality. To reduce possible differences, a (PSM) of 1:1 was performed with the covariates (i.e., age, male, female, hypertension, CAD, diabetes, COPD, smoking history, body mass index < 30). This resulted in a matched cohort (n=118/118) over a 275 day time frame.
Results
A log-rank test illustrated survival probability at end of time window that the SARS-COV-2 TAVR group had a (75.2% vs 89.5%, P=<0.05) compared to the non-SARS-COV-2 TAVR group and is illustrated in Figure 1.
Conclusions
It appears that within our group of SARS-COV-2 TAVR, patients have a higher all-cause mortality in the unmatched and matched group based on the log rank test. The SARS-COV-2 TAVR group had a high prevalence of hypertension, CAD, diabetes, COPD, and BMI.
