Sex-Based Differences in Patients Undergoing Percutaneous Mitral Valve Repair: A Meta-analysis

Background
Female patients are more frail and have a distinct risk profile compared to males. Sex-based differences in patients undergoing percutaneous mitral valve repair with MitraClip have not been studied

Methods
PubMed, EMBASE and Google Scholar databases were queried for all trials about MitraClip. Trials reporting sex-based outcomes were included

Results
This meta-analysis of 5 trials included 1587 patients, of whom 609 (38%) were females, undergoing MitraClip procedure. Female patients compared to males had similar acute procedural success (OR 0.99, 95% CI 0.60- 1.64), numerically females were more likely to get a single clip but differences were not statistically significant (OR 1.24, 95% CI 0.35- 4.40). NYHA functional class improvement was similar for both females and males after MitraClip (OR 0.86, 95% CI 0.63- 1.18).

Conclusions
In this meta-analysis, female patients, compared to males, had similar acute procedural success and NYHA functional class improvement after transcatheter mitral valve repair with MitraClip device. This analysis supports percutaneous mitral valve repair for symptomatic females when appropriate