Peripheral Vascular Disease in Patients with Obstructive Sleep Apnea- A Systematic Review

Ahsan, Muhammad Junaid

Peripheral Vascular Disease in Patients with Obstructive Sleep Apnea- A Systematic Review

Tuesday, May 21, 2019

Belmont Ballroom 2-3 (The Cosmopolitan of Las Vegas)

Muhammad Junaid Ahsan , Creighton University, Omaha, NE

Hafiz Muhammad Fazeel , Services Institute of Medical Sciences, Lahore, Pakistan

Aravdeep Jhand , Creighton University School of Medicine, omaha, NE

Syeda Sabeeka Batool , University of Alabama School of Medicine, Huntsville, AL

Noman Lateef , Creighton University School of Medicine, omaha, NE, Pakistan

Siddiqiue Mohyud Din Chaudhary , Einstein Medical Center, philadelphia, PA

Soban Ahmad , Hamad General hospital, Qatar, Qatar

Mohsin Mirza , CHI health Creighton University Medical Canter, omaha, NE, Pakistan

Background
The influence of OSA on the development of PAD is not well established. Our systematic review helps to understand the mutual prevalence and association of sleep apnea and PAD.

Methods
PubMed, Ovid Embase, Web of science, Cochrane library, and clinicaltrials.gov databases were searched up to 11/29/2018. 744 articles were screened. Original studies reporting prevalence or other association of PAD in patients with known or suspected OSA were considered.

Results
Eleven prospective studies with N= 63642, including 27882 males and 35,494 females. Mean (SD) age: 59.6+/- 13.2 years to 71.1+/- 9.8 years. OSA patients= 10,628 (16.7%) and PAD patients= 13,068 (20.5%). Except for two studies, all studies reported an increased prevalence of OSA in PAD. Schaefer et al and Adam et al found a significant association between two conditions even when the data was adjusted for age, hyperlipidemia, diabetes, smoking and systemic hypertension (OR = 5.426, 95 % CI [1.068; 27.567]) P< 0.001 and (OR = 1.60, P < 0.001) (adjusted OR = 1.37, P = 0.014) respectively. In the subgroup analysis, three studies found statistically significant reduction in CPWV with increasing severity of OSA. Data was conflicting regarding the association of OSA severity with pulse wave index and intermittent claudication. And OSA severity was reported to have no association with ABI values.

Conclusions
OSA patients have a high prevalence of PAD. But the association was not homogenous across all testing variables for the two diseases. Further prospective clinical trials are required to delineate the mutual incidence and the potential association between the two conditions.